Must Reads
Lanz TV, Brewer RC, Ho PP, Moon JS, Jude KM, Fernandez D, Fernandes RA, Gomez AM, Nadj GS, Bartley CM, Schubert RD, Hawes IA, Vazquez SE, Iyer M, Zuchero JB, Teegen B, Dunn JE, Lock CB, Kipp LB, Cotham VC, Ueberheide BM, Aftab BT, Anderson MS, DeRisi JL, Wilson MR, Bashford-Rogers RJM, Platten M, Garcia KC, Steinman L, Robinson WH. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature. 2022 Mar;603(7900):321-327. doi: 10.1038/s41586-022-04432-7. PMCID: PMC9382663.
We analyze the single cell B cell repertoire in cerebro-spinal fluid and blood of patients with multiple sclerosis (MS) and demonstrate that Epstein-Bar virus (EBV) contributes to MS via molecular mimicry.
Brewer RC, Ramadoss NS, Lahey LJ, Jahanbani S, Robinson WH*, Lanz TV*. BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2. Nature Immunology. 2022, 23(1):33-39. doi: 10.1038/s41590-021-01088-9. PMCID: PMC8776031
We discern the acute B cell response to RBD and S2 protein in SARS-CoV-2 vaccinated individuals, using single-cell RNA sequencing, single-cell B cell repertoire sequencing, and analyses of human-derived monoclonal antibodies.
Murphy KA, Bhamidipati K, Rubin SJS, Kipp L, Robinson WH*, Lanz TV*. Immunomodulatory receptors are differentially expressed in B and T cell subsets relevant to autoimmune disease. Clin Immunol. 2019, 209:108276. doi:10.1016/j.clim.2019.108276. PMID: 31669582 (*co-senior and co-corresponding)
We investigate expression levels of immunomodulatory receptors in B and T cells in autoimmune disease using high-parameter flow cytometry.